Mouse anti-human a-Synuclein

Product name

Anti-alpha-synuclein antibody

Description

Mouse monoclonal [LB 509] to alpha-synuclein

Host species: Mouse

Proven applications

Suitable for: WB, Flow Cyt

Species reactivity

Reacts with: Rat, Human, Recombinant Fragment

Immunogen

Whole-body protein. This information is the property of Abcam and/or its suppliers.

Epitope

ab27766 reacts with an epitope located in the region encoded by amino acids 115-122 of alpha-synuclein.

Positive control

WB: human recombinant alpha-synuclein protein. Flow Cyt: PC12 cells (differentiated with NGF).

General Notes

This antibody clone is manufactured by Abcam. Alpha-synuclein is predominantly expressed in the brain, where it is concentrated in the presynaptic nerve endings. The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillar aggregates in neurons or glial cells is a characteristic lesion in a subset of neurodegenerative disorders. These disorders include Parkinson’s disease (PD), Lewy body dementia (DLB), and multiple system atrophy, collectively called synucleinopathies.

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. The life sciences industry has been on the brink of a reproducibility crisis for several years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please verify that this product meets your needs before purchasing.

Properties

Form: Liquid

Storage instructions

Shipped at 4 ° C. Upon delivery, take an aliquot and store it at -20 ° C or -80 ° C. Avoid repeated freeze/thaw cycles.

Storage buffer

  • pH: 7.40
  • Preservative: 0.02% sodium azide
  • Components: PBS, 6.97% L-Arginine

Concentration: 100 µg to 1 mg / ml

Purity: Immunogenic affinity purified

Clonality: Monoclonal

Cloning number: LB 509

Isotype: IgG1

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