Mouse anti-human a-Synuclein
Product name
Anti-alpha-synuclein antibody
Description
Mouse monoclonal [LB 509] to alpha-synuclein
Host species: Mouse
Proven applications
Suitable for: WB, Flow Cyt
Species reactivity
Reacts with: Rat, Human, Recombinant Fragment
Immunogen
Whole-body protein. This information is the property of Abcam and/or its suppliers.
Epitope
ab27766 reacts with an epitope located in the region encoded by amino acids 115-122 of alpha-synuclein.
Positive control
WB: human recombinant alpha-synuclein protein. Flow Cyt: PC12 cells (differentiated with NGF).
General Notes
This antibody clone is manufactured by Abcam. Alpha-synuclein is predominantly expressed in the brain, where it is concentrated in the presynaptic nerve endings. The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillar aggregates in neurons or glial cells is a characteristic lesion in a subset of neurodegenerative disorders. These disorders include Parkinson’s disease (PD), Lewy body dementia (DLB), and multiple system atrophy, collectively called synucleinopathies.
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. The life sciences industry has been on the brink of a reproducibility crisis for several years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please verify that this product meets your needs before purchasing.
Properties
Form: Liquid
Storage instructions
Shipped at 4 ° C. Upon delivery, take an aliquot and store it at -20 ° C or -80 ° C. Avoid repeated freeze/thaw cycles.
Storage buffer
- pH: 7.40
- Preservative: 0.02% sodium azide
- Components: PBS, 6.97% L-Arginine
Concentration: 100 µg to 1 mg / ml
Purity: Immunogenic affinity purified
Clonality: Monoclonal
Cloning number: LB 509
Isotype: IgG1
